Drug Rash with eosinophilia and systemic symptoms versus Stevens-Johnson Syndrome–a case that indicates a stumbling block in the current classification
R Wolf, B Davidovici, H Matz, K Mahlab… - International archives of …, 2006 - karger.com
R Wolf, B Davidovici, H Matz, K Mahlab, E Orion, ZM Sthoeger
International archives of allergy and immunology, 2006•karger.comA 43-year-old man developed a skin eruption characterized by 'macules with blisters' typical
to Stevens-Johnson syndrome, as well as erosions of the lips and buccal mucosa, 2 weeks
after he had started treatment with lamotrigine. He had a fever (39.6 C), elevated liver
enzymes and atypical lymphocytes in the peripheral blood. This undoubtedly reflects a case
of Stevens-Johnson syndrome induced by lamotrigine, but it can also fulfill the criteria of
anticonvulsant hypersensitivity syndrome or drug rash with eosinophilia and systemic signs …
to Stevens-Johnson syndrome, as well as erosions of the lips and buccal mucosa, 2 weeks
after he had started treatment with lamotrigine. He had a fever (39.6 C), elevated liver
enzymes and atypical lymphocytes in the peripheral blood. This undoubtedly reflects a case
of Stevens-Johnson syndrome induced by lamotrigine, but it can also fulfill the criteria of
anticonvulsant hypersensitivity syndrome or drug rash with eosinophilia and systemic signs …
Abstract
A 43-year-old man developed a skin eruption characterized by ‘macules with blisters’ typical to Stevens-Johnson syndrome, as well as erosions of the lips and buccal mucosa, 2 weeks after he had started treatment with lamotrigine. He had a fever (39.6 C), elevated liver enzymes and atypical lymphocytes in the peripheral blood. This undoubtedly reflects a case of Stevens-Johnson syndrome induced by lamotrigine, but it can also fulfill the criteria of anticonvulsant hypersensitivity syndrome or drug rash with eosinophilia and systemic signs. A case that precisely fits the definition of two syndromes that have different characteristics, different treatments and different prognoses indicates that there is a flaw in the classification.
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